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Their commentary and data were published in a recent issue of the British medical journal The Lancet Infectious Diseases Vol. Many factors may account for this lack of efficacy. However, Giuliano and colleagues suggest that the high prevalence of HPV among the HIV-infected men 73 percent in the intervention group and 69 percent in the control group and the high prevalence of HIV among the female partners of greater than 60 percent, relates to the lack of efficacy of male circumcision. In that study, it was pointed out that the high and sustained prevalence of HPV among the HIV-infected individuals is "likely to overwhelm any preventative effect of circumcision.

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